Long Noncoding RNA Malat1 Regulates Cerebrovascular Pathologies in Ischemic Stroke
نویسندگان
چکیده
منابع مشابه
Induction of long noncoding RNA MALAT1 in hypoxic mice
Long thought to be "junk DNA", in recent years it has become clear that a substantial fraction of intergenic genomic DNA is actually transcribed, forming long noncoding RNA (lncRNA). Like mRNA, lncRNA can also be spliced, capped, and polyadenylated, affecting a multitude of biological processes. While the molecular mechanisms underlying the function of lncRNAs have just begun to be elucidated, ...
متن کاملLong noncoding RNA MALAT1 regulates endothelial cell function and vessel growth.
RATIONALE The human genome harbors a large number of sequences encoding for RNAs that are not translated but control cellular functions by distinct mechanisms. The expression and function of the longer transcripts namely the long noncoding RNAs in the vasculature are largely unknown. OBJECTIVE Here, we characterized the expression of long noncoding RNAs in human endothelial cells and elucidat...
متن کاملThe Long Noncoding RNA MALAT1 Regulates Endothelial Cell Function and Vessel Growth
1Institute of Cardiovascular Regeneration, University Frankfurt, Frankfurt, Germany; 2Max-DelbrückCentrum für Molekulare Medizin (MDC), Berlin-Buch, Germany; 3GeorgSpeyer-Haus, Institute for Tumor Biology and Experimental Tumor Therapy, Frankfurt, Germany; 4Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany, and; 5German Center for Cardiovascular Research (DZHK), Partner sit...
متن کاملThe nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation.
Alternative splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased transcriptome and proteomic complexity. The serine/arginine (SR) splicing factors regulate tissue- or cell-type-specific AS in a concentration- and phosphorylation-dependent manner. However, the mechanisms that modulate the cellular levels of active SR proteins remain to be elucidated. In the present stu...
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With the advent of next-generation sequencing technology, there is rapidly increasing interest in long noncoding RNAs (lncRNAs). The objectives of this study were to develop a novel lncRNA MALAT1 near-infrared optical probe, to evaluate the characteristics of this optical imaging probe in vitro and to determine whether it can be used for imaging MALAT1 expression in malignant tumours in vivo. C...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2017
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3389-16.2017